Hi Barclay, the energy molecule is ATP, made by the mitochondria from glucose metabolites and Oxygen. Remember the formula Glucose + Oxygen —> ENERGY+ water + carbon dioxide?
In this scenario glucose donates its electrons to oxygen and in the process of breaking bonds energy is produced. That energy is stored in ATP a molecule that cells use to operate their proteins. So for regular ATP production the fuel is glucose metabolites.

When you run out of oxygen and/or glucose to power the ATP making process, your muscles use a different form of fuel to make ATP: phosphocreatine and glycogen.

These molecules are long term emergency stores that take a while to be processed and transported around the body. If your muscles find it difficult to use Oxygen to make muscles they are constantly tapping into their glycogen and phoshocreatine reserves. This makes it a much slower prorcess to refill the stores sitting in their cells for emergency.

It’s like if you start using a savings account to pay your bills- it takes a lot longer to replace those savings if you have to keep dipping in cos there’s no money in your current account.

Did this this help? Happy to answer any questions I can!

In an article in 2023 in the journal of Nature which contrasted HIV funding (mostly men) to ME/CFS (mostly women) and found that ME/CFS is now only funded .04 of disease burden because of the effects of the pandemic. (2)

In 2019, PNAS published a potential diagnostic test and drug screen for ME/CFS from a nanoelectronic device called the Nanoneedle that measures electrical impedence. The Nanoneedle can distinguish between ME/CFS patients and healthy controls with 100% accuracy. The reason for this accuracy is that it can take 200 measurements per second. The Nanoneedle works by using a salt solution to cause the cells to expend energy to pump it out mimicing the effects of a 2-Day CPET without the CPET.

The Nanoneedle was developed with grants from the NIH in order to meaure proteins in Cancer but the developers, with funding from the Open Medicine Foundation, tested it in ME/CFS patients. The Nanoeedle was developed to measure ANY protein, not just the ME/CFS proteins. But in 2020, when the Pandemic hit, and it was obvious that there would be a huge influx of ME/CFS patients, rather than speeding the development of this amazing diagnostic test- the NIH chose to bury it, going as far as asking the developers not to apply again- and NIH grant reviewers used the old discimination against ME/CFS patients to refuse them. Rather than fund a futuristic diagnostic test – NIH grant reviewers did spend $3.7 Million dollars of ME/CFS funding on a Non-ME/CFS project. (4)

In 2019, the NIH held a Conference to “Accelerate ME/CFS Research”. The Conference came with no accompanying funding announcements, and rather than accelerating research funding, calling for a consensus defintion, or writing a biomarker discovery roadmpa- the NIH chose to decrease ME/CFS funding to $13 Million dollars.

NIH ME/CFS funding should be $600 Million dollars a year and that should be repeated in every article about ME/CFS.

References
1. Arthur A. Mirin, Mary E. Dimmock & Leonard A. Jason (2022) Updated ME/CFS prevalence estimates reflecting post-COVID increases and associated economic costs and funding implications, Fatigue: Biomedicine, Health & Behavior, 10:2, 83-93, DOI: 10.1080/21641846.2022.2062169

2. (2023). Women’s health: End the disparity in funding. Nature. https://doi.org/10.1038/d41586-023-01472-5

3. Esfandyarpour, R.; Kashi, A.; Nemat-Gorgani, M.; Wilhelmy, J.; Davis, R.W. A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Proc. Natl. Acad. Sci. USA 2019, 116, 10250–10257 https://doi.org/10.1073/pnas.1901274116

4. https://trialbyerror.org/2023/04/14/why-did-the-nih-list-an-award-for-research-on-cancer-related-fatigue-in-its-list-of-spending-on-me-cfs/

Thanks for the tip,we have added additional information.

In addition it is the most uneconomical method to distribute any drug/chemical. People drink less than 1% of the water delivered to them So 99% is flushed down the drain in washers, toilets, washing the dog, etc.
Over 99% of the money communities spend on fluoride is flushed directly down the drain.
It is an absolute waste of tax money.